| Achievement/Trophy | How to Unlock |
| Rite of Passage | Reach level 10. |
| Demon Slayer | Reach level 30. |
| Hero of Sanctuary | Reach level 60. |
| Demon Slayer (Hardcore) | Reach level 30 in Hardcore mode. |
| The Mad King’s End | Kill the Skeleton King in Normal mode. |
| The Mad King’s End (Inferno) | Kill the Skeleton King in Inferno mode. |
| Butchered! | Kill the Butcher in Normal mode. |
| Butchered! (Inferno) | Kill the Butcher in Inferno mode. |
| The Coven Overthrown | Kill Maghda in Normal mode. |
| The Coven Overthrown (Inferno) | Kill Maghda in Inferno mode. |
| The Lord of Lies | Kill Belial in Normal mode. |
| The Lord of Lies (Inferno) | Kill Belial in Inferno mode. |
| The Lord of Sin | Kill Azmodan in Normal mode. |
| The Lord of Sin (Inferno) | Kill Azmodan in Inferno mode. |
| The Prime Evil | Kill Diablo in Normal mode. |
| The Prime Evil (Nightmare) | Kill Diablo in Nightmare mode. |
| The Prime Evil (Hell) | Kill Diablo in Hell mode. |
| The Prime Evil (Inferno) | Kill Diablo in Inferno mode. |
| The Last of the Horadrim | Complete all quests in Act I. |
| The Black Soulstone | Complete all quests in Act II. |
| The Wages of Sin | Complete all quests in Act III. |
| Victory and Sacrifice | Complete all quests in Act IV. |
| Fresh Meat | Complete all the Butcher triumph challenges. |
| Out of the Shadows | Complete all the Belial triumph challenges. |
| Azmodone | Complete all the Azmodan triumph challenges. |
| Diabolical | Complete all the Diablo triumph challenges. |
| Rarely There | Equip a rare (yellow) item. |
| Legends of the Brawl | Equip a legendary (orange) item. |
| Armed to the Teeth | Equip all Inventory slots with items that have a minimum required level of 25 or higher. |
| Prepared for Battle | Equip all Inventory slots with items that have a minimum required level of 60 or higher. |
| The Comfort of Strangers | Recruit the Templar, Scoundrel, and Enchantress. |
| Friends with Benefits | Fully equip one of your followers. |
| The Art of Conversation | Complete all the main character, follower, and artisan conversation challenges. |
| Breaking Not So Bad | Use a merchant to repair an item. |
| Shut Up and Take My Money! | Buy each type of item from merchants. |
| Bejeweled | Combine gems. |
| Made to Order | Craft 5 items. |
| A Life with Meaning | Raise the Blacksmith to level 10. |
| Just a Hobby | Raise the Jeweler to level 10. |
| Deep Pockets | Pick up 500,000 gold. |
| All That Glitters | Pick up 5,000,000 gold. |
| Space! I Love Space! | Buy all stash upgrades. |
| The Elitist | Kill 500 elite (champion, rare, or unique) enemies. |
| Greed over Need | Kill 100 Treasure Goblins. |
| Never Seen that Before | Kill one of the unique enemies listed in the Never Seen That Before Challenge. |